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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
In immunology, clonal deletion is the process of removing T and B lymphocytes from the immune system repertoire. [1] [2] The process of clonal deletion helps prevent recognition and destruction of the self host cells, making it a type of negative selection. Ultimately, clonal deletion plays a role in central tolerance. [3]
David Talmage (1919-2014), clonal selection theory; James S. Tan (1927-2006) Reyes Tamez (1952-) Kevin J. Tracey (1957-) Jan Vilcek (1933-) Ellen Vitetta; Alexander S. Wiener (1907-1976) Don Wiley (1944-2001), crystallography of HLA proteins; Ian Wilson (biologist) Ernst Witebsky (1901-1969), isolation and partial characterization of A and B ...
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
The theory is now sometimes known as Burnet's clonal selection theory, [113] which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection. [114] Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962.
The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. [1] This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with ...
Clonal deletion, a process by which B cells and T cells are deactivated before act significantly upon specific antigens; Clonal selection theory, a model for how the immune system responds to infection; Clonal anergy, a lack of reaction by the body's defense mechanisms to foreign substance
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