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  2. Schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Schizophrenia

    The question of how schizophrenia could be primarily genetically influenced, given that people with schizophrenia have lower fertility rates, is a paradox. It is expected that genetic variants that increase the risk of schizophrenia would be selected against, due to their negative effects on reproductive fitness .

  3. Risk factors of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Risk_factors_of_schizophrenia

    Evidence suggests that it is the interaction between genes and the environment may be associated with the development of schizophrenia. [2] This is a complex process involving multiple environmental factors that have influence on a range of developmental periods that interact with a genetic susceptibility. [7]

  4. Psychiatric genetics - Wikipedia

    en.wikipedia.org/wiki/Psychiatric_genetics

    If possible to test for schizophrenia before the symptoms develop, proactive interventions could be developed, or even preventative treatments. [7] In one study, 100% of patients with bipolar disorder indicated that they would probably take a genetic test to determine they were carrying a gene associated with the disorder, if such a test ...

  5. Evolution of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Evolution_of_Schizophrenia

    The self-domestication hypothesis for evolution of schizophrenia observes the importance our self-domesticated evolution, with emphasis on its contribution to the altered genetic development of the neural crest and our relaxed social cultural niche. Adaptations related these domesticated changes favored the emergence of complex cognitive ...

  6. Diagnosis of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Diagnosis_of_schizophrenia

    Although many genetic variants associated with schizophrenia have been identified, their effects are usually very small, so they are combined onto a polygenic risk score. [55] These scores, despite accounting for hundreds of variants, only explain up to 6% in symptom variation and 7% of the risk for developing the disease. [35]

  7. Endophenotype - Wikipedia

    en.wikipedia.org/wiki/Endophenotype

    The next major use of the term was in psychiatric genetics, to bridge the gap between high-level symptom presentation and low-level genetic variability, such as single nucleotide polymorphisms. [5] It is therefore more applicable to more heritable disorders, such as bipolar disorder and schizophrenia. [6]

  8. Schizotypy - Wikipedia

    en.wikipedia.org/wiki/Schizotypy

    Rado proposed the term 'schizotype' to describe the person whose genetic make-up gave them a lifelong predisposition to schizophrenia. The quasi-dimensional model is so called because the only dimension it postulates is that of gradations of severity or explicitness in relation to the symptoms of a disease process: namely schizophrenia.

  9. Evolutionary approaches to schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Evolutionary_Approaches_to...

    Polimeni and Reiss' group selection hypothesis of schizophrenia emphasizes the shamanism, or shaman-like behaviors, arguing that there is a need to consider the genetic root of such behaviors. [2] One related hypothesis argues that schizophrenia helps maintain charismatic leaders who utilize symptoms, such as paranoia and delusions, to create ...

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