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For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.
There are various competing calculation methods for the drug accumulation ratio, yielding somewhat different results. A commonly used formula defines R ac as the ratio of the area under the curve (AUC) during a single dosing interval under steady state conditions to the AUC during a dosing interval after one single dose: [1]
AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [ 5 ] Bioavailability of a drug is an average value ; to take population variability into account, deviation range is shown as ± . [ 4 ]
Appropriate use criteria (AUC), sometimes referred to as appropriateness criteria (AC), specify when it is appropriate to perform a medical procedure or service. An "appropriate" procedure is one for which the expected health benefits exceed the expected health risks by a wide margin.
Beyond AUC exposure measures, parameters such as Cmax (maximum concentration), Tmax (time to maximum concentration), CL and Vd can also be reported using NCA methods ...
Experts say that a man’s sperm health does, in fact, play an important role not only in conception but also in the health of the pregnancy, the mother and the future little human — and that ...
A high ROC AUC, such as 0.9 for example, might correspond to low values of precision and negative predictive value, such as 0.2 and 0.1 in the [0, 1] range. If one performed a binary classification, obtained an ROC AUC of 0.9 and decided to focus only on this metric, they might overoptimistically believe their binary test was excellent.
Phi measures how better (or worse) is a classification, with respect to the random classification, which is characterized by Phi = 0. According to the reference values suggested by Cohen, [8] one can take Phi = 0.35 as a minimum acceptable level of Phi for a classification. In the ROC space, Phi equal to a non null constant corresponds to the ...