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Lamotrigine (aka Lamictal) – FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [7] The usual target dose is 100–200 mg daily, titrated to by 25 mg increments every 2 weeks. [8] Lamotrigine can cause Stevens–Johnson syndrome, a very rare but potentially fatal skin ...
Lithium orotate (C 5 H 3 LiN 2 O 4) is a salt of orotic acid and lithium.It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O. [1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissolves in solution to produce free lithium ions.
While lithium is typically the most effective treatment, possible alternatives to Lithium include Lamotrigine and Second generation Antipsychotics for the treatment of acute bipolar depression or for the management of bipolar patients with normal mood during pregnancy.
Lamotrigine is considered a first-line agent for the treatment of bipolar depression. It is effective in preventing the recurrence of both mania and depression, but it has not proved useful in treating acute mania. [2] Zonisamide (trade name Zonegran), another anti-convulsant, also may show promise in treating bipolar depression. [18]
Lithium has the best overall evidence and is considered an effective treatment for acute manic episodes, preventing relapses, and bipolar depression. [142] [143] Lithium reduces the risk of suicide, self-harm, and death in people with bipolar disorder. [144] Lithium is preferred for long-term mood stabilization. [66]
Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression; Lurasidone (Latuda) – approved as a monotherapy for bipolar depression; Quetiapine (Seroquel) – approved as a monotherapy for bipolar depression; Sulpiride – approved in low doses as a monotherapy for major depressive disorder [12]