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Saw palmetto extract has been studied in clinical trials as a possible treatment for people with prostate cancer and for men with lower urinary tract symptoms associated with BPH. [1] [3] As of 2023, there is insufficient scientific evidence that saw palmetto extract is effective for treating cancer or BPH and its symptoms.
Saw palmetto, a phytotherapeutic agent, has been shown to reduce prostatic congestion and urinary symptoms related to benign prostate hyperplasia. The exact mechanism is unknown however it is commonly believed to work by inhibiting the enzyme 5-alpha reductase that converts testosterone into dihydrotestosterone , its active metabolite . [ 23 ]
Androstanolone, or stanolone, also known as dihydrotestosterone (DHT) and sold under the brand name Andractim among others, is an androgen and anabolic steroid (AAS) medication and hormone which is used mainly in the treatment of low testosterone levels in men. [2]
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They catalyse formation of the androgens testosterone and DHT, which in turn regulate hair growth. Androgens have different effects at different follicles: they stimulate IGF-1 at facial hair, causing hair regrowth, but stimulate TGF β1, TGF β2, dickkopf1 and IL-6 at the scalp, causing hair follicle miniaturisation. [80]
Considering 30 to 50 percent of men are affected by hair loss by age 50 — it’s no surprise that some turn to herbal remedies like saw palmetto.