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The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data. In medical research, it is often used to measure the fraction of patients living for a certain amount of time after treatment.
Paul Meier (July 24, 1924 – August 7, 2011) [1] was a statistician who promoted the use of randomized trials in medicine. [2] [3]Meier is known for introducing, with Edward L. Kaplan, the Kaplan–Meier estimator, [4] [5] a method for measuring how many patients survive a medical treatment from one duration to another, taking into account that the sampled population changes over time.
Isotonic regression has applications in statistical inference.For example, one might use it to fit an isotonic curve to the means of some set of experimental results when an increase in those means according to some particular ordering is expected.
The problem with measuring overall survival by using the Kaplan-Meier or actuarial survival methods is that the estimates include two causes of death: deaths from the disease of interest and deaths from all other causes, which includes old age, other cancers, trauma and any other possible cause of death. In general, survival analysis is ...
Confidence bands can be constructed around estimates of the empirical distribution function.Simple theory allows the construction of point-wise confidence intervals, but it is also possible to construct a simultaneous confidence band for the cumulative distribution function as a whole by inverting the Kolmogorov-Smirnov test, or by using non-parametric likelihood methods.
His parents were Eugene V. Kaplan (1887–1977) and Frances Rhodes Kaplan (1891–1978). He graduated from Swissvale High School in Swissvale, Pennsylvania , in 1937. He attended the Carnegie Institute of Technology from 1937 to 1941 and graduated with a bachelor's degree in mathematics in 1941.
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Estimation statistics, or simply estimation, is a data analysis framework that uses a combination of effect sizes, confidence intervals, precision planning, and meta-analysis to plan experiments, analyze data and interpret results. [1]