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A synthetic radioisotope is a radionuclide that is not found in nature: no natural process or mechanism exists which produces it, or it is so unstable that it decays away in a very short period of time. [1] Frédéric Joliot-Curie and Irène Joliot-Curie were the first to produce a synthetic radioisotope in the 20th century. [2]
The concept was introduced in the 1950s, at a time when the deployment of nuclear weapons and nuclear reactors spurred research on the biological effects of artificial radioactivity. It had been noticed that those effects depended both on the type and energy spectrum of the radiation, and on the kind of living tissue. The first systematic ...
Synthetic antibodies include recombinant antibodies, nucleic acid aptamers and non-immunoglobulin protein scaffolds. As a consequence of their in vitro manufacturing method the antigen recognition site of synthetic antibodies can be engineered to any desired target and may extend beyond the typical immune repertoire offered by natural ...
DOTA linked to the monoclonal antibody tacatuzumab and chelating yttrium-90 Whole-body PET scan using 18 F-FDG showing intestinal tumors and non-specific accumulation in bladder Radiolabeling is a technique used to track the passage of a molecule that incorporates a radioisotope through a reaction, metabolic pathway, cell, tissue, organism, or ...
Induced radioactivity, also called artificial radioactivity or man-made radioactivity, is the process of using radiation to make a previously stable material radioactive. [1] The husband-and-wife team of Irène Joliot-Curie and Frédéric Joliot-Curie discovered induced radioactivity in 1934, and they shared the 1935 Nobel Prize in Chemistry ...
A radioimmunoassay (RIA) is an immunoassay that uses radiolabeled molecules in a stepwise formation of immune complexes.A RIA is a very sensitive in vitro assay technique used to measure concentrations of substances, usually measuring antigen concentrations (for example, hormone levels in blood) by use of antibodies.
Radioecologists evaluate the effects of both natural and artificial radioactivity on the environment itself as well as dosimetrically on the human body. Radionuclides transfer between all of Earth’s various biomes, so radioecological studies are organized within three major subdivisions of the biosphere: land environments, oceanic aquatic ...
Synthetic immunology is the rational design and construction of synthetic systems that perform complex immunological functions. [1] Functions include using specific cell markers to target cells for destruction and or interfering with immune reactions. [2]