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A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases , which cleave peptide bonds at the N-terminus of proteins.
Carboxypeptidase A and the target enzyme of Captopril, angiotensin-converting enzyme, have very similar structures, as they both contain a zinc ion within the active site. This allowed for a potent carboxypeptidase A inhibitor to be used to inhibit the enzyme and, thus, lower blood pressure through the renin-angiotensin-aldosterone system. [1]
Lysine carboxypeptidase's EC number is 3.4.17.3. The first number in an EC number indicates the main class that the enzyme belongs to (the options being oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases). Lysine carboxypeptidase belongs to class 3 which indicates that it is a hydrolase. Hydrolases use water to break ...
Carboxypeptidase M (EC 3.4.17.12, CPM) is an enzyme. [1] [2] [3] This enzyme catalyses the following chemical reaction. Cleavage of C-terminal arginine or lysine residues from polypeptides. This is a membrane-bound enzyme optimally active at neutral pH.
70574 Ensembl ENSG00000135678 ENSMUSG00000020183 UniProt P14384 Q80V42 RefSeq (mRNA) NM_001005502 NM_001874 NM_198320 NM_027468 RefSeq (protein) NP_001005502 NP_001865 NP_938079 NP_081744 Location (UCSC) Chr 12: 68.84 – 68.97 Mb Chr 10: 117.47 – 117.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carboxypeptidase M is an enzyme that in humans is encoded by the CPM gene ...
Carboxypeptidase E (CPE), also known as carboxypeptidase H (CPH) and enkephalin convertase, is an enzyme that in humans is encoded by the CPE gene. [5] This enzyme catalyzes the release of C-terminal arginine or lysine residues from polypeptides. CPE is involved in the biosynthesis of most neuropeptides and peptide hormones. [6]
Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially cleaves off basic amino acids arginine and lysine from the C-terminus of a peptide.
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene. [ 5 ] [ 6 ] [ 7 ] Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins.