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The prognosis of schizophrenia is varied at the individual level. In general it has great human and economics costs. [1] It results in a decreased life expectancy of 12–15 years primarily due to its association with obesity, little exercise, and smoking, while an increased rate of suicide plays a lesser role. [1]
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
By age and gender. Schizophrenia is diagnosed 1.4 times more frequently in males than females, and typically appears earlier in men [ 7 ] —the peak ages of onset are 20–28 years for males and 26–32 years for females. [ 9 ] Onset in childhood, before the age of 13 can sometimes occur. [ 10 ][ 11 ] A later onset can occur between the ages ...
The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have dopamine- receptor antagonistic effects.
Glutamate hypothesis of schizophrenia. The glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was initially based on a set of clinical, neuropathological, and, later, genetic findings pointing at a hypofunction of glutamatergic signaling via NMDA ...
The diagnosis of schizophrenia, a psychotic disorder, is based on criteria in either the American Psychiatric Association 's Diagnostic and Statistical Manual of Mental Disorders, or the World Health Organization 's International Classification of Diseases (ICD). [1] Clinical assessment of schizophrenia is carried out by a mental health ...
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