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Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints). [1] It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. [2]
Strontium ranelate, a strontium (II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. Studies indicate it can also slow the course of osteoarthritis of the knee. [1]
A disease-modifying osteoarthritis drug (DMOAD) is a disease-modifying drug that would inhibit or even reverse the progression of osteoarthritis. [1] Since the main hallmark of osteoarthritis is cartilage loss, a typical DMOAD would prevent the loss of cartilage and potentially regenerate it. Other DMOADs may attempt to help repair adjacent ...
Arthritis of the knee is typically a particularly debilitating form of arthritis. [1] The knee may become affected by almost any form of arthritis. [2] The word arthritis refers to inflammation of the joints. [3][4] Types of arthritis include those related to wear and tear of cartilage, such as osteoarthritis, to those associated with ...
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5][6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7] The most common symptoms are joint pain and stiffness. [1]
Chondroitin sulfate is an important structural component of cartilage, [2] and provides much of its resistance to compression. [3] Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis, although large clinical trials failed to demonstrate any symptomatic benefit of chondroitin.