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Immunodeficiency, also known as immunocompromisation, is a state in which the immune system 's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection and ...
Sophie Hambleton is a British physician who is Professor of Paediatrics and Immunology at Newcastle University. She is a clinical paediatric immunologist at the Great North Children's Hospital, which specialises in treating children with immunodeficiencies. Hambleton looks to understand the cellular and molecular basis of immune system errors.
The complement system is part of the innate as well as the adaptive immune system; it is a group of circulating proteins that can bind pathogens and form a membrane attack complex. Complement deficiencies are the result of a lack of any of these proteins. They may predispose to infections but also to autoimmune conditions. [7]
If a patient has trouble clearing one infection without getting better, however, that can be a sign of a weakened immune system. Still, being immunocompromised comes from a doctor's diagnosis and ...
Autoinflammatory diseases. Autoinflammatory diseases (AIDs) are a group of rare disorders caused by dysfunction of the innate immune system. These responses are characterized by periodic or chronic systemic inflammation, usually without the involvement of adaptive immunity. Autoinflammatory diseases are a separate class from autoimmune diseases ...
Hypogammaglobulinemia is an immune system disorder in which not enough gamma globulins are produced in the blood (thus hypo- + gamma + globulin + -emia). This results in a lower antibody count, which impairs the immune system, increasing risk of infection. Hypogammaglobulinemia may result from a variety of primary genetic immune system defects ...
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. [1][2] In general, deliberately induced immunosuppression is ...
Roseola, also known as sixth disease, is an infectious disease caused by certain types of human herpes viruses. [2] Most infections occur before the age of three. [1] Symptoms vary from absent to the classic presentation of a fever of rapid onset followed by a rash. [1][2] The fever generally lasts for three to five days, while the rash is ...
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