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Ranitidine was discovered in England in 1976 and came into commercial use in 1981. [26] It is on the World Health Organization's List of Essential Medicines. [27] [28] [29] It has been withdrawn at regulator request from most markets, including the United States; [12] according to the UK NHS, it has been discontinued globally. [30]
Ranitidine (Zantac) 2020 Worldwide Found to spontaneously break down into the carcinogen N-nitrosodimethylamine. Rapacuronium (Raplon) 2001 US, multiple markets Withdrawn in many countries because of risk of fatal bronchospasm. [2] Remoxipride: 1993 UK, others Aplastic anemia. [3] rhesus rotavirus vaccine-tetravalent (RotaShield) 1999 US
Ranitidine, a heartburn medicine sold under the brand name Zantac among others, was pulled from shelves in 2019, [1] following disclosure [2] of potential carcinogenic effects, [3] [4] which its manufacturers were accused of "engaging in a decades-long scheme to conceal." [5]
Sanofi discontinued the ranitidine formulation of Zantac, and the new formulation, Zantac 360, is made with a different active ingredient.
The FDA "has determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures," the agency wrote in a news release. ... 7 discontinued ...
NEW YORK (Reuters) -Sanofi has reached an agreement in principle to settle 4,000 U.S. lawsuits linking the discontinued heartburn drug Zantac to cancer, the company said on Wednesday. Sanofi did ...
Ranitidine was introduced in 1981 and was the world's biggest-selling prescription drug by 1988. The H 2 receptor antagonists have since largely been superseded by the even more effective proton pump inhibitors (PPIs), with omeprazole becoming the biggest-selling drug for many years.
Concerns around Zantac - known chemically as ranitidine - containing potential cancer-causing impurities started to emerge in 2018, well after generic versions of the medicine had been launched.