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These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [62] For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8]
A cannabis edible, also known as a cannabis-infused food or simply an edible, is a food item (either homemade or produced commercially) that contains decarboxylated cannabinoids (cannabinoid acids converted to their orally bioactive form) from cannabis extract as an active ingredient. [1]
A systematic review in 2014 by the American Academy of Neurology found that nabiximols was 'probably effective' for spasticity, pain, and urinary dysfunction, but wasn't supported for tremor. [20] A 2021 study, however, showed “clinically relevant symptomatic results” [21] Nabiximols has also been studied for cancer pain resistant to opioids.
CBD shares a precursor with THC and is the main cannabinoid in CBD-dominant Cannabis strains. CBD has been shown to play a role in preventing the short-term memory loss associated with THC. [29] There is tentative evidence that CBD has an anti-psychotic effect, but research in this area is limited. [30] [24]
Brompton cocktail, sometimes called Brompton mixture or Brompton's cocktail, was an elixir meant for use as a pain suppressant dosed for prophylaxis.Made from morphine or diacetylmorphine (heroin), cocaine, highly pure ethyl alcohol (some recipes specify gin), and sometimes with chlorpromazine (Thorazine) to counteract nausea, it was given to terminally ill individuals (especially cancer ...
Hash oil or cannabis oil is an oleoresin obtained by the extraction of cannabis or hashish. [1] It is a cannabis concentrate containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids .
A 2015 Cochrane review found unclear usefulness for cancer pain, [44] though other reviews have found tentative evidence of benefit. [45] [46] It is of unclear effect in hot flashes in people with breast cancer. [47] The effects of aromatherapy are unclear with no peer-reviewed research in regards to cancer treatment. [48]
Clinical trials comparing the use of cannabis extracts with Marinol in the treatment of cancer cachexia have demonstrated equal efficacy and well-being among subjects in the two treatment arms. [41] United States federal law currently registers dronabinol as a Schedule III controlled substance , but all other cannabinoids remain Schedule I ...