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Medium spiny neurons have two primary phenotypes (characteristic types): D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. [ 2 ] [ 3 ] [ 4 ] Most striatal MSNs contain only D1-type or D2-type dopamine receptors , but a subpopulation of MSNs exhibit both phenotypes.
Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body. Most spines have a bulbous head (the spine head), and a thin neck that connects the head of the spine to the shaft of the dendrite. The dendrites of a single neuron can contain hundreds to thousands of spines.
The D1-type medium spiny neurons mediate reward-related cognitive processes, [5] [35] [36] whereas the D2-type medium spiny neurons mediate aversion-related cognition. [6] The neurons in the core, as compared to the neurons in the shell, have an increased density of dendritic spines, branch segments, and terminal segments.
The mesolimbic pathway and a specific set of the pathway's output neurons (e.g. D1-type medium spiny neurons within the nucleus accumbens) play a central role in the neurobiology of addiction. [20] [21] [22] Drug addiction is an illness caused by habitual substance use that induces chemical changes in the brain's circuitry. [23]
A neuron, neurone, [1] or nerve ... Medium spiny neurons, most neurons in the corpus striatum; ... Dopamine is a neurotransmitter that acts on D1 type (D1 and D5) Gs ...
Spinal neurons are specialized nerve cells located within the spinal cord. [1] They are a crucial component of the central nervous system.These neurons play vital roles in transmitting and processing information between the brain and the rest of the body.
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
The disinhibition of the thalamus leads to activation of the prefrontal cortex and ventral striatum, selective for increased D1 activity leading to reward. [28] There is also evidence from non-human primate and human electrophysiology studies that other basal ganglia structures including the globus pallidus internus and subthalamic nucleus are ...