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High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). [1] [2] It may be referred to simply as prostatic intraepithelial neoplasia (PIN).
This recognizes that prostatic carcinomas have multiple patterns and that prognosis is more accurately determined by adding the scores of the two most prevalent patterns. Using this system, the grades of the most prevalent and second most prevalent patterns (if at least 5% of the total), are added together to yield the overall Gleason score.
However, high magnification (right image) shows the key feature of prominent nucleoli (visible at 200x magnification to make the diagnosis of "high-grade"), as well as other typical features of HGPIN. Reference for features: - Margaret Sanders, M.B.B.Ch., Murali Varma, M.B.B.S.. High grade prostatic intraepithelial neoplasia (HGPIN).
This article incorporates text from a free content work. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) license. (license statement/permission). Text taken from adenocarcinoma Prostate adenocarcinoma , Patholines.
Data-driven prognostics usually use pattern recognition and machine learning techniques to detect changes in system states. [3] The classical data-driven methods for nonlinear system prediction include the use of stochastic models such as the autoregressive (AR) model, the threshold AR model, the bilinear model, the projection pursuit, the multivariate adaptive regression splines, and the ...
The high prevalence of WBCs and positive bacterial cultures in the asymptomatic control population raises questions about the clinical usefulness of the standard Meares–Stamey four-glass test as a diagnostic tool in men with CP/CPPS. [37] By 2000, the use of the four-glass test by American urologists was rare, with only 4% using it regularly ...