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The Site Master file contains specific and factual GMP information about the production and control of pharmaceutical manufacturing operations carried out at the named site and any closely integrated operations at adjacent and nearby buildings. If only part of a pharmaceutical operation is carried out on the site, the site master file needs to ...
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. The word formulation is often used in a way that includes dosage form .
Galenic formulation is named after Claudius Galen, a 2nd Century AD Greek physician, who codified the preparation of drugs using multiple ingredients. Today, galenic formulation is part of pharmaceutical formulation. The pharmaceutical formulation of a medicine affects the pharmacokinetics, pharmacodynamics and safety profile of a drug.
Beginning with a mixture of polymer and solvent (top), cosolvents encourage the aggregation of polymers (right), simplifying production and improving performance. Without the use of cosolvent, droplets of primary solvent coalesce into distinct domains and polymer is more randomly dispersed (left). Adapted from Janssen et al (2015).
Ethanol has the advantage of being an excellent solvent for both acidic and basic (alkaline) constituents. A tincture using glycerine is called a glycerite. Glycerine is generally a poorer solvent than ethanol. Vinegar, being acidic, is a better solvent for obtaining alkaloids but a poorer solvent for acidic components.
It is typically used for separation of proteins, [10] because the organic solvents used in normal-phase chromatography can denature many proteins. Today, RP-LC is a frequently used analytical technique. There are huge variety of stationary phases available for use in RP-LC, allowing great flexibility in the development of the separation methods.
Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious. [2] Organochlorides such as trichloroethylene, tetrachloroethylene, dichloromethane and chloroform are commonly used as solvents and are referred to as "chlorinated solvents". [citation needed]
This is due to the untested or pharmaceutically unacceptable solvents and gelators commonly used in organogel synthesis. [5] Organogels that are used pharmaceutically include microemulsion-based gels and lecithin gels. [5] Some manufacturers decide to use organogels as a medium for drug delivery due to its potentially emollient effect.