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The trophoblast (from Greek trephein: to feed; and blastos: germinator) is the outer layer of cells of the blastocyst. Trophoblasts are present four days after fertilization in humans. [ 1 ] They provide nutrients to the embryo and develop into a large part of the placenta .
"Cytotrophoblast" is the name given to both the inner layer of the trophoblast (also called layer of Langhans) or the cells that live there.It is interior to the syncytiotrophoblast and external to the wall of the blastocyst in a developing embryo.
The epiblast gives rise to the three germ layers of the developing embryo during gastrulation (endoderm, mesoderm, and ectoderm). The trophoblast is a layer of cells forming the outer ring of the blastocyst that combines with the maternal endometrium to form the placenta. Trophoblast cells also secrete factors to make the blastocoel. [25]
Image showing trophoblast differentiated into the two layers of cytotrophoblast and syncytiotrophoblast during implantation. It is the outer layer of the trophoblasts and actively invades the uterine wall, during implantation, rupturing maternal capillaries and thus establishing an interface between maternal blood and embryonic extracellular fluid, facilitating passive exchange of material ...
The trophoblast will also develop two sub-layers: the cytotrophoblast, which is in front of the syncytiotrophoblast, which in turn lies within the endometrium. [10] Next, another layer called the exocoelomic membrane or Heuser's membrane will appear and surround the cytotrophoblast, as well as the primitive yolk sac. [11]
The chorion consists of two layers: an outer formed by the trophoblast, and an inner formed by the extra-embryonic mesoderm. The trophoblast is made up of an internal layer of cubical or prismatic cells, the cytotrophoblast or layer of Langhans, and an external multinucleated layer, the syncytiotrophoblast .
Sheela Sathyanarayana, MD, MPH, a professor in the University of Washington Department of Pediatrics and the Department of Environmental and Occupational Health Sciences, worries that the harm ...
The blastocoel further expands and the inner cell mass becomes positioned on one side of the trophoblast cells forming a mammalian blastula, called a blastocyst. The axis formed by the inner cell mass and the blastocoel is the first axis of symmetry of mammalian embryo and determines its attachment point to the uterus.