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Scanning electron micrograph of SARS virions. Severe acute respiratory syndrome (SARS) is the disease caused by SARS-CoV-1. It causes an often severe illness and is marked initially by systemic symptoms of muscle pain, headache, and fever, followed in 2–14 days by the onset of respiratory symptoms, [13] mainly cough, dyspnea, and pneumonia.
[2] Travel restrictions reduced the spread of the virus, but because they were first implemented after community spread had established in several countries in distant parts of the world—they produced only a modest reduction in the total number of people infected. Travel restrictions may be most important at the start and end of the pandemic. [3]
SARS‑CoV‑2 is a strain of the species Betacoronavirus pandemicum (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. [ 2 ] [ 17 ] There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus.
SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [13] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [14]
Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), [1] [2] while more lethal varieties can cause SARS, MERS and COVID-19. [3] [4] As of 2021, 45 species are registered as coronaviruses, [5] whilst 11 diseases have been identified, as listed below.
From the early outbreak of the COVID-19 pandemic, rumors and speculation arose about the possible lab origins of SARS-CoV-2, the causative agent of the COVID-19 disease.. Different versions of the lab origin hypothesis present different scenarios in which a bat-borne progenitor of SARS-CoV-2 may have spilled over to humans, including a laboratory-acquired infection of a natural or engineered vir
SARS was a relatively rare disease; at the end of the epidemic in June 2003, the incidence was 8,422 cases with a case fatality rate (CFR) of 11%. [5] No cases of SARS-CoV-1 have been reported worldwide since 2004. [6] In December 2019, a second strain of SARS-CoV was identified: SARS-CoV-2. [7]
The 2002–2004 outbreak of SARS, caused by severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), infected over 8,000 people from 30 countries and territories, and resulted in at least 774 deaths worldwide. [1] The outbreak was first identified in Foshan, Guangdong, China, in November 2002. [2]