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Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.
Paul Hendrick Sugarbaker (born November 28, 1941, in Baltimore) is an American surgeon at the Washington Cancer Institute.He is known for developments in surgical oncology of the abdomen, including cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy, [1] or HIPEC, a treatment alternately referred to as the Sugarbaker Procedure.
Among colorectal cancer patients with peritoneal carcinomatosis cytoreductive surgery, with the addition of HIPEC can be used to prolong overall survival in patients. [5] In a typical case an incision is made from the sternum down to the pelvis, and cancerous cells are removed.
After Greg had eight rounds of chemo, as well as the stomach-removal surgery, he was cancer-free for about a year. Then the cancer came back in the peritoneum, the lining of his abdomen.
HITOC is the chest counterpart of HIPEC. Traditionally used in the treatment of malignant mesothelioma, a primary malignancy of the pleura, this modality has recently been evaluated in the treatment of secondary pleural malignancies (e.g. thymic tumors, secondary pleural carcinosis).
Based on the principle that cancer cells normally dies at 40 °C, somatic cells remains unaffected since they die at 44 °C. [30] This novel method is proven effective with only 10% recurrence rate and no mortality recorded. [31] It is known as the hyperthermic intraperitoneal chemotherapy (HIPEC), containing docetaxel, and cisplatin. [31]
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