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p21 Cip1 (alternatively p21 Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, [5] though is primarily associated with inhibition of CDK2.
cIAP1 (also named BIRC2) is the abbreviation for a human protein, cellular inhibitor of apoptosis protein-1. It belongs to the IAP family of proteins and therefore contains at least one BIR (baculoviral IAP repeat) domain.
The p27 Kip1 gene has a DNA sequence similar to other members of the "Cip/Kip" family which include the p21 Cip1/Waf1 and p57 Kip2 genes. In addition to this structural similarity the "Cip/Kip" proteins share the functional characteristic of being able to bind several different classes of Cyclin and Cdk molecules.
El-Deiry made the discoveries of the consensus binding site for p53 and the discovery of WAF1 while working with Bert Vogelstein at Johns Hopkins University. p21(WAF1) was the first mammalian cell cycle inhibitor to be discovered, and was found independently by Wade Harper and Steve Elledge as a CDK2-interacting protein p21(CIP1), [19] Yue ...
A Customer Identification Program (CIP) is a United States requirement, where financial institutions need to verify the identity of individuals wishing to conduct financial transactions with them and is a provision of the USA Patriot Act.
Donald Trump was the scourge of corporate America after the Jan.6, 2021, riots at the US Capitol. Social media companies such as Facebook and Google suspended Trump’s accounts. Dozens of big ...
New congestion pricing will lead to cars being charged up to $27 total to cross into Manhattan during the day with van and truck drivers facing even higher costs — and firefighters, teachers and ...
The Common Industrial Protocol (CIP) is an industrial protocol for industrial automation applications. It is supported by ODVA.. Previously known as Control and Information Protocol, [1] CIP encompasses a comprehensive suite of messages and services for the collection of manufacturing automation applications – control, safety, synchronization, motion, configuration and information.