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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.
Estradiol acetate is a synthetic estrane steroid and the C3 acetate ester of estradiol. [3] It is also known as estradiol 3-acetate or as estra-1,3,5(10)-triene-3,17β-diol 3-acetate. [3] Another common ester of estradiol in use for oral administration is estradiol valerate, which is a C17β ester of estradiol. [8] [23]
[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.
Estrogen, alongside other hormones, works to optimize the efficiency of your bodily functions. ... HRT can cause side effects like the risk of stroke or heart disease, so it’s important to talk ...
Side effects of estradiol dipropionate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [17] Estradiol dipropionate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] It is an estrogen ester and a prodrug of estradiol in the body.
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