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Histopathology of eosinophilic esophagitis, showing multiple intraepithelial eosinophils (bilobed cells with reddish cytoplasm on H&E stain), and edema seen as white clearings. Endoscopic mucosal biopsy remains the gold standard diagnostic test for EoE and is required to confirm the diagnosis. [8]
The treatment of lymphocytic esophagitis is still undefined. [5] Treatment either targets symptoms, inflammation or complications. For example, heartburn is a symptom in lymphocytic esophagitis, and proton pump inhibitors , which reduce acidity in the stomach, are consequently used for treatment.
[30] [31] Mepolizumab and benralizumab are other treatment options that target the alpha subunit of the IL-5 receptor, thereby inhibiting its function and reducing the number of developing eosinophils as well as the number of eosinophils leading to inflammation through antibody-dependent cell-mediated cytotoxicity and eosinophilic apoptosis.
Depending on eosinophil target-organ infiltration, the clinical presentation of hypereosinophilic syndrome (HES) varies from patient to patient. [13] Individuals with myeloproliferative variant HES may be more likely to experience mucosal ulcerations involving the genitalia or airways, while patients with lymphocytic variant HES typically exhibit prominent skin symptoms such as urticarial ...
Duodenal lymphocytosis, sometimes called lymphocytic duodenitis, lymphocytic duodenosis, or duodenal intraepithelial lymphocytosis, is a condition where an increased number of intra-epithelial lymphocytes is seen in biopsies of the duodenal mucosa when these are examined microscopically.
Eosinophilic ulcer of the tongue, [1] Riga–Fede disease, [1] Eosinophilic ulcer of the oral mucosa – H&E stain Eosinophilic ulcer of the oral mucosa (also known as traumatic eosinophilic granuloma [ 1 ] ) is a condition characterized by an ulcer with an indurated and elevated border. [ 2 ]
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Eosinopenia is a condition where the number of eosinophils, a type of white blood cell, in circulating blood is lower than normal. [1] Eosinophils are a type of granulocyte and consequently from the same cellular lineage as neutrophils, basophils, and mast cells.