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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
CIN and SIL are graded from 1 to 3 based on the degree of change observed. CIN 1, 2, and 3 all represent pre-cancerous findings. [14] CIN 1, also known as low-grade SIL, is the most benign finding. This represents very few atypical cells found, and generally, these cells will revert to normal. [14] CIN 2 and 3, also known as high-grade SIL ...
The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) and early stage cervical cancer discovered on colposcopic examination. In the UK, it is known as large loop excision of the transformation zone (LLETZ).
Cervical intraepithelial neoplasia (CIN), spanning a bit more than 2/3 of the thickness of the cervical epithelium. Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an epithelium. The exact dividing line between dysplasia and neoplasia has been very difficult to draw throughout the era of ...
This disease can progress to invasive cancer (squamous cell carcinoma) of the cervix. Cervical squamous intraepithelial lesion (SIL), previously called cervical intraepithelial neoplasia (CIN), is a form of dysplasia that can progress to cervical cancer. The term carcinoma in situ may be used interchangeably with high-grade SIL. [8]
Doctors did, in fact, find CIN III cells, which she wrote would likely have become cancer. In removing these cells and this tissue, though, she said they "practically took out" her entire cervix ...
Cervical cancer typically develops from precancerous changes called cervical intraepithelial neoplasia over 10 to 20 years. [3] About 75% of cervical cancers are squamous cell carcinomas, 20-25% are adenocarcinoma, 3% are adenosquamous carcinomas and less than 1% are small cell neuroendocrine tumors of the cervix. [19]
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