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The concept of the tumor microenvironment (TME) dates back to 1863 when Rudolf Virchow established a connection between inflammation and cancer. However, it was not until 1889 that Stephen Paget's seed and soil theory introduced the important role of TME in cancer metastasis, highlighting the intricate relationship between tumors and their surrounding microenvironment.
In humans, gut microecology is the study of the microbial ecology of the human gut which includes gut microbiota composition, its metabolic activity, and the interactions between the microbiota, the host, and the environment. [3] Research in human gut microecology is important because the microbiome can have profound effects on human health.
Microenvironment (biology), a small or relatively small usually distinctly specialized and effectively isolated biophysical environment (as of a nerve cell) Microenvironment (ecology) , also known as a microhabitat, a very small, specific area in a habitat, distinguished from its immediate surroundings by factors such as the amount of incident ...
These include the buccal region (especially cavities in the gingiva), rumen, caecum etc. of mammalian herbivores or even invertebrate digestive tracts.In the case of mammalian gastrointestinal microecology, microorganisms such as protozoa, bacteria, as well as curious incompletely defined organisms (such as certain large structurally complex Selenomonads, Quinella ovalis "Quin's Oval ...
Microbial ecology (or environmental microbiology) is the ecology of microorganisms: their relationship with one another and with their environment. It concerns the three major domains of life— Eukaryota , Archaea , and Bacteria —as well as viruses . [ 2 ]
Research interests span many aspects of soil ecology and microbiology. Fundamentally, researchers are interested in understanding the interplay among microorganisms , fauna , and plants, the biogeochemical processes they carry out, and the physical environment in which their activities take place, and applying this knowledge to address ...
A major component of studies of microbiomes of the built environment involves determining how components of the built environment impact these microbes and microbial communities. Factors that are thought to be important include humidity, pH, chemical exposures, temperature, filtration, surface materials, and air flow. [68]
At the micro level, also referred to as the local level, the research population typically is an individual in their social setting or a small group of individuals in a particular social context. Examples of micro levels of analysis include, but are not limited to, the following individual analysis type approach: