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Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Vitamin D (the inactive version) is mainly from two forms: vitamin D 3 and vitamin D 2. Vitamin D 3, or cholecalciferol, is formed in the skin after exposure to sunlight or ultra violet radiation or from D 3 supplements or fortified food sources. Vitamin D 2, or ergocalciferol, is obtained from D 2 supplements or fortified food sources. [3]
Taking vitamin D supplements has no significant effect on cancer risk. [98] Vitamin D 3, however, appears to decrease the risk of death from cancer but concerns with the quality of the data exist. [99] Nevertheless, studies suggest that Vitamin D deficiency is associated with increased risk of development melanoma. [100]
Coroner’s records show the 89-year-old had taken NaturPlus UK vitamin D supplements for at least nine months before his death. ... these risks and side effects to be written [on] the packaging ...
A third important effect of PTH on the kidneys is stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol). [221] This form of vitamin D is the active hormone which promotes calcium uptake from the intestine via the action of calbindin . [ 223 ]
Dietary supplement companies have aggressively marketed NMN products, claiming those benefits. [8] However, no human studies to date have properly proven its anti-aging effects with proposed health benefits only suggested through research done in vitro or through animal models . [ 9 ]