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A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5. The structures of vardenafil and sildenafil are similar, they both contain similar structured purine ring of cGMP that contributes their features to act as a competitive inhibitor of PDE5.
Xanthines such as caffeine and theobromine are cAMP-phosphodiesterase inhibitors. However, the inhibitory effect of xanthines on phosphodiesterases are only seen at dosages higher than what people normally consume. [citation needed] Sildenafil, Tadalafil and Vardenafil are PDE-5 inhibitors and are widely used in the treatment of erectile ...
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
8654 242202 Ensembl ENSG00000138735 ENSMUSG00000053965 UniProt O76074 Q8CG03 RefSeq (mRNA) NM_033437 NM_001083 NM_033430 NM_153422 RefSeq (protein) NP_001074 NP_236914 NP_246273 NP_700471 Location (UCSC) Chr 4: 119.49 – 119.63 Mb Chr 3: 122.52 – 122.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC ...
Download as PDF; Printable version; In other projects ... Pages in category "PDE5 inhibitors" The following 23 pages are in this category, out of 23 total.
1.1 cGMP phosphodiesterase inhibitors. 2 See also. 3 Sources. ... Download QR code; Print/export Download as PDF; Printable version; In other projects Wikidata item ...
Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; Appearance. ... PDE5 inhibitors (23 P) PDE7 inhibitors (1 P) PDE9 inhibitors (3 P)