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H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function. There are four known histamine receptors: H 1 receptor H1 Receptors: These receptors are primarily located on smooth muscle cells, endothelial cells, and neurons.
The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart, and in the central nervous system .
The gene sequence for H 3 receptors expresses only about 22% and 20% homology with both H 1 and H 2 receptors respectively. There is much interest in the histamine H 3 receptor as a potential therapeutic target because of its involvement in the neuronal mechanism behind many cognitive disorders and especially its location in the central nervous ...
Histamine H 3 receptor: Located in the central nervous system and to a lesser extent peripheral nervous system tissue Autoreceptor and heteroreceptor functions: decreased neurotransmitter release of histamine, acetylcholine, norepinephrine, serotonin. Modulates nociception, gastric acid secretion, and food intake. [23] Histamine H 4 receptor
Pages in category "Histamine receptors" The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. H. Histamine H1 receptor;
59340 225192 Ensembl ENSG00000134489 ENSMUSG00000037346 UniProt Q9H3N8 Q91ZY2 RefSeq (mRNA) NM_001143828 NM_001160166 NM_021624 NM_153087 RefSeq (protein) NP_001137300 NP_001153638 NP_067637 NP_694727 Location (UCSC) Chr 18: 24.46 – 24.48 Mb Chr 18: 13.14 – 13.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The histamine H 4 receptor, like the other three histamine receptors ...
H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. [5] PKA functions to phosphorylate certain proteins, affecting their ...
Histaminergic means "working on the histamine system", and histaminic means "related to histamine". [1] A histaminergic agent (or drug) is a chemical which functions to directly modulate the histamine system in the body or brain. Examples include histamine receptor agonists and histamine receptor antagonists (or antihistamines).