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Formic acid, topical, is a common treatment for plantar warts, which works by being applied over a period of time, causing the body to reject the wart. [ 17 ] Fluorouracil cream, a chemotherapy agent sometimes used to treat skin cancer , can be used on particularly resistant warts, by blocking viral DNA and RNA production and repair.
It is used as a medication to treat genital warts and plantar warts, including in people with HIV/AIDS. [2] [3] It is not recommended in HPV infections without external warts. Application by a healthcare provider to the skin is recommended. [2] Common side effects include redness, itchiness, and pain at the site of use.
The most common side effects of podophyllotoxin cream are typically limited to irritation of tissue surrounding the application site, usually burning, redness, pain, itching, and swelling. [14] Application is sometimes immediately followed by burning or itching. Small sores, itching, and peeling skin may also follow.
There are also strains of HPV that do not cause warts at all. According to Cleveland Clinic and Healthline, types of warts include: Common warts. Plantar warts. Genital warts. Mosaic warts. Flat warts
In a 2002 study for the treatment of warts, the responders consisted of 135 individuals (87.7%) that had complete clearance of warts. Reported adverse effects were local and included with pruritus (itching) (15.6%), with blistering (7.1%), and with eczematous reactions (eczema)(14.2%). The majority of the patients tolerated the treatment very well.
Bleomycin — A more potent chemotherapy drug, can be injected into deep warts, destroying the viral DNA or RNA. Bleomycin is notably not US FDA approved for this purpose. Possible side effects include necrosis of the digits, nail loss and Raynaud syndrome. The usual treatment is one or two injections. [25] [26]