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  2. Mouse model of colorectal and intestinal cancer - Wikipedia

    en.wikipedia.org/wiki/Mouse_model_of_colorectal...

    Azoxymethane (AOM) is a genotoxic colonic carcinogen and is routinely used to induce colon tumours in mice. [30] The AOM-induced tumours form in the last three centimeters of the distal colon but a p21 knock out mouse treated with AOM shows tumour distribution throughout the colon. [ 31 ]

  3. Megacolon - Wikipedia

    en.wikipedia.org/wiki/Megacolon

    A human colon is considered abnormally enlarged if it has a diameter greater than 12 cm [3] in the cecum (it is usually less than 9 cm [4]), greater than 6.5 cm [3] in the rectosigmoid region and greater than 8 cm [3] for the ascending colon. The transverse colon is usually less than 6 cm in diameter. [4] A megacolon can be either acute or ...

  4. Colorectal adenoma - Wikipedia

    en.wikipedia.org/wiki/Colorectal_adenoma

    The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion of the colorectal adenocarcinoma ( colon cancer ). [ 1 ] [ 2 ] [ 3 ] They often manifest as colorectal polyps .

  5. Colon cut-off sign - Wikipedia

    en.wikipedia.org/wiki/Colon_cut-off_sign

    The colon cut-off sign is a radiographic finding seen on abdominal radiographs and computed tomography scans. It is characterized by a marked dilatation of the transverse colon, with an abrupt transition to collapsed distal colon, particularly the splenic flexure. [1] This sign is indicative of underlying pathology, most commonly acute ...

  6. Colorectal cancer - Wikipedia

    en.wikipedia.org/wiki/Colorectal_cancer

    Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). [5] Signs and symptoms may include blood in the stool , a change in bowel movements , weight loss, abdominal pain and fatigue. [ 9 ]

  7. Malignant transformation - Wikipedia

    en.wikipedia.org/wiki/Malignant_transformation

    Colon cancer provides one example of the mechanisms by which diet, the top factor listed in the table, is an external factor in cancer. The Western diet of African Americans in the United States is associated with a yearly colon cancer rate of 65 per 100,000 individuals, while the high fiber/low fat diet of rural Native Africans in South Africa is associated with a yearly colon cancer rate of ...

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