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In the field of molecular biology, the ETS (E26 transformation-specific [2] or Erythroblast Transformation Specific [3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila.
ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
Ets1 directly interacts with various transcription factors. Their interaction results in formation of multiprotein complexes. When Ets1 interacts with other transcription factors (Runx1, Pax5, TFE3, and USF1) its final effect on transcription depends on whether C-terminal domain is phosphorylated.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator.It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences.
2114 23872 Ensembl ENSG00000157557 ENSMUSG00000022895 UniProt P15036 P15037 RefSeq (mRNA) NM_001256295 NM_005239 NM_011809 RefSeq (protein) NP_001243224 NP_005230 NP_035939 Location (UCSC) Chr 21: 38.81 – 38.82 Mb Chr 16: 95.5 – 95.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this ...
Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus ().Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.
E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. [5] In humans this protein is encoded by the ELF2 gene . [ 6 ]
The human ETV6 protein is a member of the ETS transcription factor family; however, it more often acts to inhibit than stimulate transcription of its target genes.ETV6 protein contains 3 domains: a) the pointed N-terminal (i.e. PNT) domain which forms oligomer partners with itself as well as other transcription factors (e.g. FLI1) and is required for ETV6's transcriptional repressing activity ...