Search results
Results From The WOW.Com Content Network
Myc is a family of regulator genes and ... transcribed genes through the recruitment of transcriptional ... and CD40 signaling in regulation of microRNAs (miR-29, miR ...
Rearrangement of dimers (e.g., Mad:Max, Max:Myc) provides a system of transcriptional regulation with greater diversity of gene targets. Max must dimerise in order to be biologically active. [7] Transcriptionally active hetero- and homodimers involving Max can promote cell proliferation as well as apoptosis. [8]
Transcriptional addiction is a concept in cancer biology where cancer cells become heavily reliant on abnormal transcriptional programs to sustain their survival, growth, and proliferation. This addiction occurs because cancer cells often have dysregulated gene expression pathways, allowing them to evade normal cellular processes such as ...
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor.
17428 Ensembl ENSG00000070444 ENSMUSG00000000282 UniProt Q99583 O08789 RefSeq (mRNA) NM_020310 NM_010813 RefSeq (protein) NP_064706 NP_034943 Location (UCSC) Chr 17: 2.38 – 2.4 Mb Chr 11: 74.72 – 74.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene Function The Myc Mad network comprises a ...
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is ...
Specifically, two biogenesis regulators—PGC1α and c-Myc—can be targeted to prevent cancer proliferation. PGC1α is a key component in mitochondrial biogenesis—as a transcriptional coactivator, it targets multiple transcription factors and the estrogen-related receptor alpha (ERRα). [25]
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. [ 5 ] [ 6 ] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.