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Diverticular disease is when problems occur due to diverticulosis, a benign condition defined by the formation of pouches (diverticula) from weak spots in the wall of the large intestine. [1] This disease spectrum includes diverticulitis , symptomatic uncomplicated diverticular disease (SUDD), and segmental colitis associated with ...
CT scan showing extensive diverticulosis of the sigmoid colon Diverticular disease Whole slide of a transverse section of the left colon with diverticulosis. Diverticulosis is defined by the presence of multiple pouches (diverticula) in the colon. [22] In people without symptoms, these are usually found incidentally during other investigations.
Mesalamine is an anti-inflammatory medication used in the treatment of inflammatory bowel diseases. [68] In limited studies, patients with diverticulitis and symptomatic diverticular disease treated with mesalamine have shown improvement in both conditions. [69] Mesalazine may reduce recurrences in symptomatic uncomplicated diverticular disease ...
Having said that, the exact relationship between fiber and having diverticula (with and without symptoms) is not very clear, but dietary fiber is associated with a decreased risk of symptomatic diverticular disease, and on the flip side a diet high in fatty foods and red meat is associated with an increased risk of symptomatic diverticular disease.
While a low-fiber diet is generally used for acute diverticulitis, the NIH guidelines recommend a high-fiber diet for patients with diverticulosis (a condition that may lead to diverticulitis). [17] A Mayo Clinic review from 2011 showed that a high-fiber diet can prevent diverticular disease.
Urethral diverticula are often asymptomatic [2] and symptoms that are present tend to be nonspecific. [1] They can co-occur with cancer, in approximately 6-9% of cases, most commonly adenocarcinoma, but also including squamous cell carcinoma and transitional cell carcinoma. Approximately 10% of cases co-occur with kidney stones. [3]
A Meckel's diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine present at birth and a vestigial remnant of the vitelline duct.It is the most common malformation of the gastrointestinal tract and is present in approximately 2% of the population, [1] with males more frequently experiencing symptoms.
A combination of alverine citrate and simeticone (ACS) for irritable bowel syndrome therapy were compared with placebo in a phase IV clinical trial. [8] At week 4, the alverine citrate and simeticone group had lower VAS scores for abdominal pain/discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%, OR = 1.3; P = 0.01) as compared with the placebo group.