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Self-amplifying mRNA (saRNA) vaccines replicate their mRNA after transfection. [100] Self-amplifying mRNA has two open reading frames. The first frame, like conventional mRNA, codes for the antigen of interest. The second frame codes for an RNA-dependent RNA polymerase (and its helper proteins) which replicates the mRNA construct in the cell.
Vaccine efficacy differs from vaccine effectiveness in the same way that an explanatory clinical trial differs from an intention-to-treat trial [clarification needed]: vaccine efficacy shows how effective a vaccine could be given ideal circumstances and 100% vaccine uptake (such as the conditions within a controlled clinical trial); vaccine effectiveness measures how well a vaccine performs ...
A study among pre-surgical patients across the Mayo Clinic system in the United States, showed that mRNA vaccines were 80% protective against asymptomatic infections. [420] A UK study found that a single dose of the Oxford–AstraZeneca COVID-19 vaccine is about 73% (27 – 90%) effective in people aged 70 and older. [421]
Single pediatric doses for children 5 to 11 contain 10 μg of mRNA, while doses given in a series for children 6 months to 4 years contain 3 μg of mRNA. Spikevax is the brand name of Moderna’s ...
The mRNA vaccines were developed and approved for use at unprecedented speed, and demonstrated over 90% efficacy. In addition to vaccines for infectious diseases, mRNA has potential applications in treatment of cancer, cardiovascular and metabolic diseases [59] [60] [61] including ischemia. [62]
How COVID‑19 vaccines work. The video shows the process of vaccination, from injection with RNA or viral vector vaccines, to uptake and translation, and on to immune system stimulation and effect. Part of a series on the COVID-19 pandemic Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom. COVID-19 (disease) SARS-CoV-2 (virus) Cases Deaths ...
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