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A cholera vaccine is a vaccine that is effective at reducing the risk of contracting cholera. [10] The recommended cholera vaccines are administered orally to elicit local immune responses in the gut, where the intestinal cells produce antibodies against Vibrio cholerae, the bacteria responsible for the illness. This immune response was poorly ...
[33] [5] This cholera toxin contains 5 B subunits that plays a role in attaching to the intestinal epithelial cells and 1 A subunit that plays a role in toxin activity. Colonization of the small intestine also requires the toxin coregulated pilus (TCP), a thin, flexible, filamentous appendage on the surface of bacterial cells.
Prevention methods against cholera include improved sanitation and access to clean water. [5] Cholera vaccines that are given by mouth provide reasonable protection for about six months, and confer the added benefit of protecting against another type of diarrhea caused by E. coli . [ 2 ]
Infection prevention and control is the discipline concerned with preventing healthcare-associated infections; a practical rather than academic sub-discipline of epidemiology. In Northern Europe , infection prevention and control is expanded from healthcare into a component in public health , known as "infection protection" ( smittevern ...
Ribbon diagram of cholera toxin. From Ribbon diagram of pertussis toxin. S1 is the A subunit, and S2-S5 make up the B subunit. [3] Ribbon diagram of shiga toxin (Stx) from Shigella dysenteriae, showing the characteristic AB5 structure.
These programs have addressed key issues such as infant mortality, disease prevention, and access to local healthcare for mothers and their babies. By 1915 child health had become a priority. Progressive Era reformers state by state focused on rescuing children under age 10 or 12 from low-wage employment in factories.
The 2008 Zimbabwean cholera outbreak was an epidemic of cholera affecting much of Zimbabwe from August 2008 until June 2009. The outbreak began in Chitungwiza in Harare Metropolitan Province in August 2008, then spread throughout the country so that by December 2008, cases were being reported in all 10 provinces . [ 6 ]
Some scientists opposed the new theory, and even drank cholera cultures to disprove it: Koch announced his discovery of the cholera vibrio in 1884. His conclusions were based upon the constant finding of the peculiar "comma bacillus" in the stools of cholera patients, and the failure to demonstrate this organism in the feces of other persons.