Search results
Results From The WOW.Com Content Network
Methemoglobinemia may be acquired. [7] Classical drug causes of methemoglobinemia include various antibiotics (trimethoprim, sulfonamides, and dapsone [8]), local anesthetics (especially articaine, benzocaine, prilocaine, [9] and lidocaine [10]), and aniline dyes, metoclopramide, rasburicase, umbellulone, chlorates, bromates, and nitrites. [11]
In methemoglobinemia, drug-induced oxidative stress causes the oxidation of the Fe 2+ ion within the heme molecule in hemoglobin to Fe 3+, forming excessive amounts of methemoglobin. Methemoglobin is unable to bind to oxygen causing the individual to be unable to oxygenate their tissues. [ 13 ]
Hypoxemia, methemoglobinemia, and hypoxia: Duration: 100-120 days (lifespan of red blood cells) Causes: Sulfur medications such as phenacetin, metoclopramide, dapsone, phenzopyridine, and trimethoprim-sulfamethoxazole; hydrogen-sulfide-producing intestinal bacteria, such as Morganella morganii: Risk factors: Pulmonary arteriovenous malformation ...
In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. It is known that more than 150 drugs can cause this type of hemolytic anemia ...
Isobutyl nitrite is one of the compounds used as poppers, an inhalant drug that induces a brief euphoria. Isobutyl nitrite is known to cause methemoglobinemia. [28] Severe methemoglobinemia may be treated with methylene blue. [29] Gross pathology of a normal brain and a brain of a patient treated with methylene blue before death.
Another was that by virtue of being a combination drug, it was less likely to cause drug resistance. However, because dapsone causes hemolytic anemia in patients with G6PD deficiency, and because G6PD deficiency affects 10-25% of the population of sub-Saharan Africa, it was discovered that Lapdap is not safe for use in Africa.
According to the Cleveland Clinic, the medication is used for the management and treatment of methemoglobinemia, a rare condition in which hemoglobin decreases its ability to carry oxygen ...
The structure of cytochrome b5 reductase, the enzyme that converts methemoglobin to hemoglobin. [1]Methemoglobin (British: methaemoglobin, shortened MetHb) (pronounced "met-hemoglobin") is a hemoglobin in the form of metalloprotein, in which the iron in the heme group is in the Fe 3+ state, not the Fe 2+ of normal hemoglobin.