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The main goal of electrical synapses is to synchronize electrical activity among populations of neurons. [3] The first electrical synapse was discovered in a crayfish nervous system. [3] Chemical synaptic transmission is the transfer of neurotransmitters or neuropeptides from a presynaptic axon to a postsynaptic dendrite. [3]
Chemical signaling between neurons is mediated by neurotransmitters, neuropeptides, hormones, neuromodulators, and many other types of signaling molecules. Many neurological diseases arise due to an imbalance in the brain's neurochemistry. For example, in Parkinson's Disease, there is an imbalance in the brain's level of dopamine.
An electrical synapse, or gap junction, is a mechanical and electrically conductive synapse, a functional junction between two neighboring neurons. The synapse is formed at a narrow gap between the pre- and postsynaptic neurons known as a gap junction .
Typically, neurotransmitter receptors are located on the postsynaptic neuron, while neurotransmitter autoreceptors are located on the presynaptic neuron, as is the case for monoamine neurotransmitters; [45] in some cases, a neurotransmitter utilizes retrograde neurotransmission, a type of feedback signaling in neurons where the neurotransmitter ...
The basic kinds of connections between neurons are synapses: both chemical and electrical synapses. The establishment of synapses enables the connection of neurons into millions of overlapping, and interlinking neural circuits. Presynaptic proteins called neurexins are central to this process. [5]
Neurons are the information-processing cells of the nervous system: they sense our environment, communicate with each other via electrical signals and chemicals called neurotransmitters which generally act across synapses (close contacts between two neurons, or between a neuron and a muscle cell; note also extrasynaptic effects are possible, as ...
The researchers used RNA sequencing and brain-mapping tools to analyze more than 1.2 million brain cells from young mice (2 months old) and older mice (18 months old).
They send these signals in the form of electrochemical impulses traveling along thin fibers called axons, which can be directly transmitted to neighboring cells through electrical synapses or cause chemicals called neurotransmitters to be released at chemical synapses.