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Hydroxocobalamin, also known as vitamin B 12a and hydroxycobalamin, is a vitamin found in food and used as a dietary supplement. [1] As a supplement it is used to treat vitamin B12 deficiency including pernicious anemia. [1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
Vitamin B 12 supplements are available as single or multivitamin tablets. Pharmaceutical preparations of vitamin B 12 may be given by intramuscular injection. [6] [62] Since there are few non-animal sources of the vitamin, vegans are advised to consume a dietary supplement or fortified foods for B 12 intake, or risk serious health consequences. [6]
Vitamin B 12 cannot be produced by the human body, and must be obtained from the diet. [2] The body normally gets enough vitamin B 12 from the consumption of foods from animal sources. [ 2 ] Inadequate dietary intake of animal products such as eggs, meat, milk, fish, fowl (and some types of edible algae) can result in a deficiency state. [ 135 ]
They are given by injection. [2] Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
Whether methylcobalamin administration in treating vitamin B12 deficiency is inferior or superior to other forms of cobalamin remains uncertain. While directly providing active cobalamin forms to deficient patients is an attractive approach, it is not known whether methylcobalamin can reach its intracellular targets in its original, unmodified ...