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Studies performed on humans, dogs, and cats in the 1870s suggested that the production of oocytes (immature egg cells) stops at or shortly after birth. A review of reports from 1900 to 1950 by zoologist Solomon Zuckerman cemented the belief that females have a finite number of oocytes that are formed before they are born. This dogma has been ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 22 January 2025. Union of gametes of opposite sexes during the process of sexual reproduction to form a zygote This article is about fertilisation in animals and plants. For fertilisation in humans specifically, see Human fertilization. For soil improvement, see Fertilizer. "Conceive" redirects here. For ...
An oocyte (/ ˈ oʊ ə s aɪ t /, oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum, or egg cell. An oocyte is produced in a female fetus in the ovary during female gametogenesis. The female germ cells produce a primordial germ cell (PGC), which then undergoes mitosis ...
As a follicle grows in size and the antrum develops, more layers of cumulus oophorus cells accumulate around the oocyte to aid in the acrosome reaction and sperm penetration into the oocyte. The proximity between the cumulus oophorus cells and the oocyte favors bidirectional communication, which is vital for oocyte development.
Human fertilization is the union of an egg and sperm, occurring primarily in the ampulla of the fallopian tube. [1] The result of this union leads to the production of a fertilized egg called a zygote , initiating embryonic development .
The zona pellucida is a translucent matrix of cross-linked glycoprotein filaments that surrounds the mammalian oocyte and is 6.5–20 μm thick depending on the species. Its formation, which depends on a conserved zona pellucida-like (ZP) module that mediates the polymerization of egg coat components, [2] is critical to successful fertilization. [3]
Cortical granule (CG) distribution within cortex of human oocyte at metaphase II. Cortical granules are regulatory secretory organelles (ranging from 0.2 um to 0.6 um in diameter) found within oocytes and are most associated with polyspermy prevention after the event of fertilization. [1]
Since the discovery of sperm attraction to the female gametes in ferns over a century ago, [1] sperm guidance in the form of sperm chemotaxis has been established in a large variety of species [2] Although sperm chemotaxis is prevalent throughout the Metazoa kingdom, from marine species with external fertilization such as sea urchins and corals, to humans, [2] [3] [4] much of the current ...