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Risks of cataracts: Nafoxidine: 180–240 mg/day 1976 31% Cataracts, ichthyosis, photophobia: Tamoxifen 20–40 mg/day 1971–1973 31% Transient thrombocytopenia a: Footnotes: a = "The particular advantage of this drug is the low incidence of troublesome side effects (25)." "Side effects were usually trivial (26)." Sources: [107] [113]
Tamoxifen is more promiscuous than raloxifene in target sites because of the relationship between ER's amino acid in Asp-351 and the antiestrogenic side chain of the SERM. The side chain for tamoxifen cannot neutralize Asp-351, so the site allosterically influences AF-1 at the proximal end of the ER. This issue is mended with the second ...
Tamoxifen. Typically used to treat breast cancer, tamoxifen has been shown to prevent the progression of Peyronie’s disease in vitro when combined with the ED medication tadalafil.
Other side effects of estrogens include an increased risk of blood clots, cardiovascular disease, and, when combined with most progestogens, breast cancer. [1] In men, estrogens can cause breast development , feminization , infertility , low testosterone levels , and sexual dysfunction among others.
Breast Cancer Survivors: Chemotherapy, selective estrogen receptor modulators (e.g. Tamoxifen and Raloxifene), or aromatase inhibitors (e.g. Letrozole, Anastrozole, and Exemestane) can lead to decreased estrogen levels and therefore side effects that include atrophic vaginitis. [6] [13] Cigarette smoking [14]
More serious side effects may include fever, loss of appetite, joint pain, difficulty breathing or swallowing, and yellowing of the skin or eyes. [ 10 ] [ 11 ] Seeing a health professional regularly, taking progestin, having pelvic and breast exams, lowering blood pressure, and lowering cholesterol may reduce the likelihood of developing severe ...
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