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Landau–Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, [1] or aphasia with convulsive disorder, is a rare neurological syndrome that develops during childhood. [2] It is named after William Landau and Frank Kleffner, who characterized it in 1957 with a diagnosis of six children. [3] [4]
Developmental regression is associated with diagnoses of autism spectrum disorder, [3] childhood disintegrative disorder, [4] Rett syndrome, [5] Landau-Kleffner syndrome, [6] and neuro-degenerative diseases. [7] The loss of motor, language, and social skills can be treated with occupational therapy, [8] physical therapy, [9] and speech therapy ...
sleep syndrome Landau-Kleffner syndrome: Generalized and/or focal Epileptic spasms Atonic seizures Generalized tonic-clonic seizures Myoclonic seizures Cognitive symptoms Typically severe developmental delay and intellectual disability: Other symptoms Movement disorders (chorea and/or dystonia) Cortical visual impairment
William Milton Landau (October 10, 1924 [1] – November 2, 2017) was an American neurologist who was a professor of neurology at the Washington University School of Medicine in St. Louis, Missouri. [2] It was within his specialty of stroke and movement disorders that he gained eponymous recognition for the Landau–Kleffner syndrome. [2] [3]
Frank R. Kleffner (October 10, 1925 – June 12, 2015) [1] was an American pathologist who was a professor at Washington University in St. Louis, noted for his contributions in the fields of speech and language pathology and hearing. His work with William Landau and Harold Klawans advanced his
The scientific study of the causes of developmental disorders involves many theories. Some of the major differences between these theories involves whether environment disrupts normal development, if abnormalities are pre-determined, or if they are products of human evolutionary history which become disorders in modern environments (see evolutionary psychiatry). [5]
Living among a small band of Neanderthals in what is now eastern Spain was a child, perhaps 6 years old, with Down syndrome, as shown in a remarkable fossil preserving traits in the inner ear ...
Infantile epileptic spasms syndrome (IESS) previously known as West syndrome needs the inclusion of epileptic spasms for diagnosis. [1] Epileptic spasms (also known as infantile spasms) may also occur outside of a syndrome (that is, in the absence of hypsarrhythmia and cognitive regression) - notably in association with severe brain disorders (e.g. lissencephaly).