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Hydrocodone is a highly selective full agonist of the μ-opioid receptor (MOR). [28] [54] [49] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [55] Hydrocodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly. [49]
amitriptyline – tricyclic antidepressant used to treat separation anxiety, excessive grooming dogs and cats; amlodipine – calcium channel blocker used to decrease blood pressure; amoxicillin – antibacterial; apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement
Hydrocodone diversion and recreational use have escalated due to its opioid effects. [12] In 2009 and 2010, hydrocodone was the second most frequently encountered opioid in the pharmaceutical industry.
[1] [2] It contains hydrocodone, as the bitartrate, an opioid agonist; and homatropine, as the methylbromide, a muscarinic antagonist. [ 1 ] [ 2 ] It is taken by mouth . [ 1 ] [ 2 ]
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The drug, branded as Credelio Quattro, is a single, monthly chewable tablet for dogs eight weeks of age or older, the company said. The drug is approved for the treatment of flea and tick ...