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ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. [6] It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. [6] Zidovudine was first described in 1964. [7] It was resynthesized from a public-domain formula by Burroughs Wellcome. [8]
Zidovudine (ZDV) (also known as AZT and sold as Retrovir) is an antiretroviral drug used in the prevention and treatment of HIV/AIDS. Classed as a nucleoside analogue reverse-transcriptase inhibitor, it inhibits HIV's reverse transcriptase enzyme, which copies the viral RNA into DNA and is essential for its replication. The first breakthrough ...
[2] [3] [4] It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare: [5] abacavir sulfate (ABC) lamivudine (3TC) zidovudine (AZT or ZDV) It is indicated in the treatment of AIDS/HIV-1. [2]
The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. [5] The first nucleoside reverse-transcriptase inhibitor with in vitro anti-HIV activity was zidovudine. [6] Since zidovudine was approved in 1987, six nucleosides and one nucleotide reverse-transcriptase inhibitor (NRTI) have been approved by ...
HIV-1 RT does not have proof-reading activity. This, combined with selective pressure from the drug, leads to mutations in reverse transcriptase that make the virus less susceptible to NRTIs and NNRTIs. Aspartate residues 110, 185, and 186 in the reverse transcriptase polymerase domain are important in the binding and incorporation of nucleotides.
nucleoside reverse transcriptase inhibitor: Nevirapine: non-nucleoside reverse transcriptase inhibitor: Zidovudine: nucleoside reverse transcriptase inhibitor: Clinical data; Trade names: Duovir-N, Zidovex-LN, others [1] ATC code
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