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Depression can have multiple, sometimes overlapping, origins. Depression can be a symptom of some mood disorders, some of which are also commonly called depression, such as major depressive disorder, bipolar disorder and dysthymia. [7] Additionally, depression can be a normal temporary reaction to life events, such as the loss of a loved one.
Throughout studies of anxiety and depressive disorders, scientists have been unable to locate a singular cause. The possible causes of anxiety and depression are often similar to one another and the comorbidity of the two disorders is quite high, with 60% of those with depression also having some form of anxiety disorder. [11]
Stress may also cause headaches. [64] Chronic stress and a lack of coping resources available or used by an individual can often lead to the development of psychological issues such as depression and anxiety. [65] This is particularly true regarding chronic stressors.
For example, when the brain lacks serotonin, a chemical that regulates the brain's functioning, it can lead to depression, appetite changes, aggression, and anxiety. Another cause of mental distress can be exposure to severely distressing life-threatening situations and experiences. A third cause, in very rare cases, can be inheritance.
[9] [10] Chronic stress, and a lack of coping resources available, or used by an individual, can often lead to the development of psychological issues such as delusions, [11] depression and anxiety (see below for further information). [12] Chronic stress also causes brain atrophy, which is the loss of neurons and the connections between them ...
"Depression with anxious distress" was added into the DSM-5 as a means to emphasize the common co-occurrence between depression or mania and anxiety, as well as the risk of suicide of depressed individuals with anxiety. Specifying in such a way can also help with the prognosis of those diagnosed with a depressive or bipolar disorder.