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In a nutshell, “hepatitis C is a virus that infects the liver, causing inflammation and scarring of the organ,” says K. V. Narayanan Menon, MD, the medical director of liver transplantation at ...
There is no vaccine against hepatitis C. [1] [9] Prevention includes harm reduction efforts among people who inject drugs, testing donated blood, and treatment of people with chronic infection. [ 4 ] [ 10 ] Chronic infection can be cured more than 95% of the time with antiviral medications such as sofosbuvir or simeprevir .
The hepatitis C virus (HCV) [3] is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans. [4] [5]
Sofosbuvir/velpatasvir, sold under the brand name Epclusa among others, is a fixed-dose combination medication for the treatment of hepatitis C in adults. [2] [5] [6] [7] It combines sofosbuvir and velpatasvir. [2] [5] [6] It is more than 90% effective for hepatitis C genotypes one through six. [2]
Sofosbuvir is a once-daily oral nucleotide analogue inhibitor for the treatment of chronic hepatitis C virus. Gilead Sciences has received FDA priority review status for its New Drug Application ...
Sofosbuvir is also used with other medications and longer treatment durations, depending on specific circumstances, genotype and cost-effectiveness–based perspective. For example, for the treatment of genotypes 1, 4, 5, and 6 hepatitis C infections, sofosbuvir can be used in combination with the viral NS5A inhibitor ledipasvir. [16]
Gilead Sciences' sofosbuvir has gone 4-for-4 in phase 3 trials treating hepatitis C patients. The latest data come from a trial dubbed Fusion, which tested sofosbuvir plus a generic drug called ...
The complexity of the HCV genotypes made the treatment specific for the associated genotype. The treatment for the HCV genotype also depends on the presence or absence of cirrhosis. [11] There are six major genotypes of hepatitis C virus which includes many subtypes. [12] The genotype can affect treatment of HCV infections. [3]
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