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Acetylcysteine is extensively liver metabolized, CYP450 minimal, urine excretion is 22–30% with a half-life of 5.6 hours in adults and 11 hours in newborns. [medical citation needed] Acetylcysteine is the N-acetyl derivative of the amino acid L-cysteine, and is a precursor in the formation of the antioxidant glutathione in the body.
When the NAC study began in 1976, the U.S. Food and Drug Administration (FDA) required a line that was 25% below the original. This line is referred to as the treatment line and starts at 150 μg/mL at 4 hours. It is the usual line used in the United States to determine treatment of acetaminophen overdose after the publication of the NAC study ...
In adults, the primary metabolic pathway for paracetamol is glucuronidation. [1] This yields a relatively non-toxic metabolite, which is excreted into bile and passed out of the body. A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1 ) into NAPQI, which is extremely toxic to liver ...
The rate at which a drug enters into the body for oral and other extravascular routes. 0.693 h −1: Elimination half-life: The time required for the concentration of the drug to reach half of its original value.
This page was last edited on 21 June 2011, at 21:08 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
N-acetylcysteine has been shown to decrease drug-seeking behavior for nicotine and heroin as well. However, N-acetylcysteine does not alter the cocaine-induced rush or euphoria; it only causes a reduction in drug-seeking behavior. N-acetylcysteine works by increasing levels of cysteine in cells, leading to an increase in system Xc- activity.