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State Route 381 (SR 381) is a primary state highway in the US state of Virginia. Known as Commonwealth Avenue, the state highway runs 1.21 miles (1.95 km) from the Tennessee state line north to the 1.67-mile (2.69 km) Interstate 381 (I-381) within the independent city of Bristol. In conjunction with I-381, SR 381 connects I-81 with downtown Bristol
The state highway runs 25.01 miles (40.25 km) from SR 42 near Buffalo Gap east to U.S. Route 340 (US 340) in Waynesboro. SR 254 provides a northerly alternate route to US 250 between Waynesboro and Staunton , where the highway provides access to the Woodrow Wilson Presidential Library .
The street becomes undivided shortly before the U.S. Highways reach the northern end of SR 113 (Moore Street), which heads south toward Virginia Intermont College and downtown Bristol. US 11 and US 19 continue northeast on Lee Highway, which, here and in much of Virginia is a three-lane road with center turn lane.
U.S. Route 250 (US 250) is a route of the United States Numbered Highway System, and is a spur of U.S. Route 50.It currently runs for 514 miles (827 km) from Richmond, Virginia, to Sandusky, Ohio.
U.S. Route 29 (US 29) is a major north–south route in the commonwealth of Virginia.It covers 248.0 miles (399.1 km) from the North Carolina border at the city of Danville to the Key Bridge in Washington DC.
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia.The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia.
U.S. Route 421 (US 421) is a part of the U.S. Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana.In Virginia, the U.S. Highway runs 69.23 miles (111.41 km) from the Tennessee state line between the twin cities of Bristol, Tennessee and Bristol, Virginia north and west to the Kentucky state line near St. Charles.
Major highway junctions between Winston-Salem and Boone are US 601, I-77, NC 16, Blue Ridge Parkway, US 221 and US 321. US 421 continues westerly into Tennessee towards Mountain City, Tennessee. US 421 is a limited-access freeway through Siler City northward. US 421 is a divided highway from north of NC 49 all of the way to Wilkesboro.
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