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Non-celiac gluten sensitivity (NCGS) or gluten sensitivity [14] is a controversial disorder which can cause both gastrointestinal and other problems. NCGS is included in the spectrum of gluten-related disorders. [3] [4] The definition and diagnostic criteria of non-celiac gluten sensitivity were debated and established by three consensus ...
Complex causes of autoimmune diseases often demonstrates only weak association with coeliac disease. The frequency of GSE is typically around 0.3 to 1% and lifelong risk of this form of gluten sensitivity increases in age, possibly as high as 2% for people over 60 years of age. [2]
Sensitivity may also present with extraintestinal symptoms, including headache, "brain fog", tingling and/or numbness in hands and feet, fatigue, as well as muscular disturbances and bone or joint pain; [53] [54] [55] also neuropsychiatric manifestations ("gluten-sensitive idiopathic neuropathies") have been reported on.
The alternative diagnosis of non-coeliac gluten sensitivity may be made where there is only symptomatic evidence of gluten sensitivity. [106] Gastrointestinal and extraintestinal symptoms of people with non-coeliac gluten sensitivity can be similar to those of coeliac disease, [ 16 ] and improve when gluten is removed from the diet, [ 107 ...
People with NCGS may develop gastrointestinal symptoms, which resemble those of irritable bowel syndrome or wheat allergy, [66] [38] or a wide variety of non-gastrointestinal symptoms, such as headache, chronic fatigue, fibromyalgia, atopic diseases, allergies, neurological diseases, or psychiatric disorders, among others.
Non-coeliac gluten sensitivity (NCGS) is described as a condition of multiple symptoms that improves when switching to a gluten-free diet, after coeliac disease and wheat allergy are excluded. [ 36 ] [ 37 ] People with NCGS may develop gastrointestinal symptoms, which resemble those of irritable bowel syndrome (IBS) [ 38 ] [ 39 ] or a variety ...
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