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It has been administered at daily doses of up to 300 mg without causing clinically significant adverse reactions in the literature. [8] The most commonly reported adverse effect of melatonin overdose is somnolence. [8] Upon melatonin overdose, drowsiness may be expected and the compound should be cleared within 12 hours. [8]
In humans, ~30 μg of melatonin is produced daily and 80% of the total amount is produced in the night (W). The plasma maximum concentration of melatonin at night are 80–120 pg/mL and the concentrations during the day are between 10–20 pg/mL. [76] [77]
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The lethal dose for 50% of dogs is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [38] In case of accidental intake of chocolate, especially involving a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended ...
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Study up on the major pros and cons of popping this supplement in an attempt to sleep more soundly.