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Radiation therapy kills cancer cells in two ways depending on the effective energy of the radiative source. The amount of energy deposited as the particles traverse a section of tissue is referred to as the linear energy transfer (LET). X-rays produce low LET radiation, and protons and neutrons produce high LET radiation.
The tubarial salivary glands, ... It is believed that avoiding the irradiation of the glands will prevent many of the side effects of radiotherapy, such as xerostomia.
The exact cause of malignant parotid tumors is still unknown, however they can be caused by metastasis (spread of cancer) from other areas of the body, certain work exposures, reduced immunity, HIV, as well as radiation exposure. [5] Contrary to other cancers, it is believed that smoking and drinking do not influence salivary gland malignancies ...
However, the condition may arise anywhere minor salivary glands are located. [nb 1] It has also been occasionally reported to involve the major salivary glands. [2] [3] It may be present only on one side, or both sides. [1] The lesion typically is 1–4 cm in diameter. [4] Initially, the lesion is a tender, erythematous (red) swelling. Later ...
This side effect is a result of radiation damage of the parasympathetic nerves. Formation of salivary gland ducts depends on the secretion of a neuropeptide from the parasympathetic nerves, while development of the end buds of the salivary gland depends on acetylcholine from the parasympathetic nerves. [15]
The two parotid glands are major salivary glands wrapped around the mandibular ramus in humans. [6] These are largest of the salivary glands, secreting saliva to facilitate mastication and swallowing, and amylase to begin the digestion of starches. [7] It is the serous type of gland which secretes alpha-amylase (also known as ptyalin). [8]
Thus, as with every form of treatment, radiation therapy is not without its side effects. Radiation therapy can lead to dry mouth from exposure of salivary glands to radiation, resulting in decreased saliva secretion. Post therapy, the salivary glands will resume functioning but rarely in the same fashion.
Head and neck cancer is a general term encompassing multiple cancers that can develop in the head and neck region. These include cancers of the mouth, tongue, gums and lips (oral cancer), voice box (), throat (nasopharyngeal, oropharyngeal, [1] hypopharyngeal), salivary glands, nose and sinuses.