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A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV, COVID-19, and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase that is required for replication of HIV and other retroviruses .
Phylogeny of Orthornavirae RNA-dependent polymerase. The five colored branches are the five phyla of Orthornavirae.. Both kingdoms in Riboviria show a relation to the reverse transcriptases of group II introns that encode RTs and retrotransposons, which are self-replicating DNA sequences, the latter of which self-replicate via reverse transcription and integrate themselves into other parts of ...
In order to carry out their life cycle, the retrovirus relies heavily on the host cell's machinery. Protease degrades peptide bonds of the viral polyproteins, making the separate proteins functional. Reverse transcriptase functions to synthesize viral DNA from the viral RNA in the host cell's cytoplasm before it enters the nucleus.
The human immunodeficiency ... [32] Symptoms occur in 40–90% of cases and most ... and over 30 individual drugs: nucleoside/nucleotide reverse transcriptase ...
In humans there is an association between ... there is an incubation period of about two days before symptoms appear. ... Reverse transcription-polymerase chain ...
While the exact causes of mitochondrial toxicity are unknown, research has shown that a certain group of anti-viral drugs used to treat HIV, specifically nucleoside analog reverse transcriptase inhibitors (NRTIs), interfere with an enzyme needed in the production of mitochondria.
Treatment is typically a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus two nucleoside analog reverse transcriptase inhibitors (NRTIs) Under research [3] Entamoeba histolytica: Amoebiasis: Microscopy Those with symptoms require treatment with an amoebicidal tissue-active agent and a luminal cysticidal agent.